Set in contemporary New York City, Cacaya is the story of a young Brazilian woman, who ends her tumultuous relationship with an American man, and then discovers she is carrying his child. The couple's struggle to interact during the pregnancy, and to deal with the situation, increases the tension between them. The film interweaves this modern narrative with indigenous Amazon rainforest folklore and ancient Greek mythology of the Amazons, using the framework of German dramatist Heinrich von Kleist's 1808 tragedy Penthesilea.
Eddie (Anthony Del Negro) and his friend Chris (Christopher Lenk) call out for an escort after Eddie's girlfriend (Isabella Racco) breaks up with him and moves out of their house. Little do they know that while Natasha is a breathtaking beauty, she's really a possessed doll created by a mad doctor (Don Scribner) in an unholy laboratory and built with the urge to kill and dominate the minds of others to kill for her.@